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Journal article

Connexin43 contributes to electrotonic conduction across scar tissue in the intact heart

Abstract:

Studies have demonstrated non-myocytes, including fibroblasts, can electrically couple to myocytes in culture. However, evidence demonstrating current can passively spread across scar tissue in the intact heart remains elusive. We hypothesize electrotonic conduction occurs across non-myocyte gaps in the heart and is partly mediated by Connexin43 (Cx43). We investigated whether non-myocytes in ventricular scar tissue are electrically connected to surrounding myocardial tissue in wild type and ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep26744

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Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
Role:
Author
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Funding agency for:
Mahoney, V
Grant:
12PRE11890017
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Funding agency for:
Mirams, G
Grant:
101222/Z/13/Z
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Funding agency for:
Mirams, G
Grant:
101222/Z/13/Z
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Funding agency for:
Morley, G
Grant:
HL076751
Laura and Isaac Perlmutter Cancer Center More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
6
Pages:
26744-26744
Publication date:
2016-05-31
Acceptance date:
2016-05-09
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Source identifiers:
629431
Pubs id:
pubs:629431
UUID:
uuid:2ece49e8-4e5c-47dc-9eb1-5b5a29ee96e4
Local pid:
pubs:629431
Deposit date:
2016-06-28

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