- Abstract:
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Studies have demonstrated non-myocytes, including fibroblasts, can electrically couple to myocytes in culture. However, evidence demonstrating current can passively spread across scar tissue in the intact heart remains elusive. We hypothesize electrotonic conduction occurs across non-myocyte gaps in the heart and is partly mediated by Connexin43 (Cx43). We investigated whether non-myocytes in ventricular scar tissue are electrically connected to surrounding myocardial tissue in wild type and ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 2.2mb)
-
- Publisher copy:
- 10.1038/srep26744
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- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 6
- Pages:
- 26744-26744
- Publication date:
- 2016-05-31
- DOI:
- EISSN:
-
2045-2322
- ISSN:
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2045-2322
- URN:
-
uuid:2ece49e8-4e5c-47dc-9eb1-5b5a29ee96e4
- Source identifiers:
-
629431
- Local pid:
- pubs:629431
- Copyright holder:
- Mahoney et al.
- Copyright date:
- 2016
- Notes:
- Authors retain copyright. This work is licensed under a Creative Commons Attribution 4.0 International License.
Journal article
Connexin43 contributes to electrotonic conduction across scar tissue in the intact heart
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Laura and Isaac Perlmutter Cancer Center
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