Journal article icon

Journal article

Connexin43 contributes to electrotonic conduction across scar tissue in the intact heart

Abstract:

Studies have demonstrated non-myocytes, including fibroblasts, can electrically couple to myocytes in culture. However, evidence demonstrating current can passively spread across scar tissue in the intact heart remains elusive. We hypothesize electrotonic conduction occurs across non-myocyte gaps in the heart and is partly mediated by Connexin43 (Cx43). We investigated whether non-myocytes in ventricular scar tissue are electrically connected to surrounding myocardial tissue in wild type and ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1038/srep26744

Authors


Mahoney, VM More by this author
Mezzano, V More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Computer Science
Expand authors...
More from this funder
Funding agency for:
Mirams, GR
More from this funder
Funding agency for:
Mirams, GR
Laura and Isaac Perlmutter Cancer Center More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
6
Pages:
26744-26744
Publication date:
2016-05-31
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
URN:
uuid:2ece49e8-4e5c-47dc-9eb1-5b5a29ee96e4
Source identifiers:
629431
Local pid:
pubs:629431

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP