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Abundance of megalin and Dab2 is reduced in syncytiotrophoblast during placental malaria, which may contribute to low birth weight

Abstract:

Placental malaria caused by Plasmodium falciparum contributes to ~200,000 child deaths annually, mainly due to low birth weight (LBW). Parasitized erythrocyte sequestration and consequent inflammation in the placenta are common attributes of placental malaria. The precise molecular details of placental changes leading to LBW are still poorly understood. We hypothesized that placental malaria may disturb maternofetal exchange of vitamins, lipids, and hormones mediated by the multi-ligand (n ~ ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep24508

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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Publisher:
Nature Publishing Publisher's website
Journal:
Scientific Reports Journal website
Volume:
6
Pages:
Article 24508
Publication date:
2016-04-13
Acceptance date:
2016-03-30
DOI:
ISSN:
2045-2322
Pmid:
27072056
Source identifiers:
616974

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