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A general analysis of calibrated BOLD methodology for measuring CMRO2 responses: comparison of a new approach with existing methods.

Abstract:

The amplitude of the BOLD response to a stimulus is not only determined by changes in cerebral blood flow (CBF) and oxygen metabolism (CMRO(2)), but also by baseline physiological parameters such as haematocrit, oxygen extraction fraction (OEF) and blood volume. The calibrated BOLD approach aims to account for this physiological variation by performing an additional calibration scan. This calibration typically consists of a hypercapnia or hyperoxia respiratory challenge, although we propose t...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine
Role:
Author
Journal:
NeuroImage
Volume:
60
Issue:
1
Pages:
279-289
Publication date:
2012-03-05
DOI:
EISSN:
1095-9572
ISSN:
1053-8119
URN:
uuid:2eb90c8b-e3f4-4acd-8d96-bf7b8fb0b043
Source identifiers:
269653
Local pid:
pubs:269653
Language:
English
Keywords:

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