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NMDA receptor subunit NR2A is required for rapidly acquired spatial working memory but not incremental spatial reference memory.

Abstract:

NMDA receptors (NMDARs) containing NR2A (epsilon1) subunits are key contributors to hippocampal long-term potentiation (LTP) induction in adult animals and have therefore been widely implicated in hippocampus-dependent spatial learning. Here we show that mice lacking the NR2A subunit or its C-terminal intracellular domain exhibit impaired spatial working memory (SWM) but normal spatial reference memory (SRM). Both NR2A mutants acquired the SRM version of the water maze task, and the SRM compo...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
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Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
28
Issue:
14
Pages:
3623-3630
Publication date:
2008-04-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:2eb2097c-e53f-4dfb-8ba8-3ff8461b65f8
Source identifiers:
16005
Local pid:
pubs:16005

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