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Journal article

Novel cis-regulatory modules control expression of the Hairy and Enhancer of Split-1 (HES1) transcription factor in myoblasts.

Abstract:

The expression profile of a gene is controlled by DNA sequences called cis-regulatory modules (CRMs). CRMs can function over large genomic distances and can be located many kilobases away from their target promoters. hes1 is a key developmental gene that is overexpressed in certain cancers and is a primary target of NOTCH signaling. Despite this, analysis of hes1 transcriptional control has been limited solely to its promoter. Here, we identify seven conserved DNA sequence blocks, representin...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m111.286484

Authors


Jeziorska, DM More by this author
Koentges, G More by this author
Journal:
The Journal of biological chemistry
Volume:
287
Issue:
8
Pages:
5687-5697
Publication date:
2012-02-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:2ead0b57-d3aa-4a51-883d-0a7cfdef75e1
Source identifiers:
262945
Local pid:
pubs:262945

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