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Current practice in methodology and reporting of the sample size calculation in randomised trials of hip and knee osteoarthritis: a protocol for a systematic review

Abstract:

Background: A key aspect of the design of randomised controlled trials (RCTs) is determining the sample size. It is important that the trial sample size is appropriately calculated. The required sample size will differ by clinical area, for instance, due to the prevalence of the condition and choice of primary outcome. Additionally, it will depend upon the choice of target difference assumed in the calculation. Focusing upon the hip and knee osteoarthritis population, this study aims to s...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s13063-017-2209-8

Authors


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Institution:
University of Oxford
Oxford college:
Wolfson College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Centre for Statistics in Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Population Health
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Centre for Statistics in Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Centre for Statistics in Medicine
Role:
Author
Publisher:
BioMed Central Publisher's website
Journal:
Trials Journal website
Volume:
18
Issue:
466
Pages:
1-5
Publication date:
2017-10-10
Acceptance date:
2017-09-25
DOI:
ISSN:
1745-6215
Source identifiers:
731809
Keywords:
Pubs id:
pubs:731809
UUID:
uuid:2ea3d94c-473b-4703-a160-b5ce2c898466
Local pid:
pubs:731809
Deposit date:
2017-10-02

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