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Soluble Dectin-1 as a tool to detect beta-glucans.

Abstract:
Beta-glucans are structural components of fungal cell walls which are involved in the immune recognition of fungal pathogens and possess beneficial immunomodulatory activities in isolated form. Here we have developed a soluble chimeric form of the major mammalian beta-glucan receptor, Dectin-1, and demonstrate its application for the detection and characterisation of soluble and insoluble beta-glucans, including fungal particles, using ELISA, flow cytometric and fluorescence-based microscopy assays.
Publication status:
Published

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Publisher copy:
10.1016/j.jim.2006.05.013

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Journal:
Journal of immunological methods
Volume:
314
Issue:
1-2
Pages:
164-169
Publication date:
2006-07-01
DOI:
EISSN:
1872-7905
ISSN:
0022-1759
Source identifiers:
24821

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