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A clinically relevant rodent model of the HIV antiretroviral drug stavudine induced painful peripheral neuropathy

Abstract:

HIV-associated sensory neuropathy is the most frequent manifestation of HIV disease, afflicting 40-50% of patients whose HIV disease is otherwise controlled by antiretroviral therapy. It often presents with significant neuropathic pain and is consistently associated with previous exposure to nucleoside reverse transcriptase inhibitors including stavudine (d4T), which is widely used in resource-limited settings. Here we investigated complex pain-related behaviours associated with d4T treatment...

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Publisher copy:
10.1016/j.pain.2012.12.023

Authors


Olausen, HR More by this author
Bathgate, G More by this author
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Journal:
Pain
Volume:
154
Issue:
4
Pages:
560-575
Publication date:
2013-04-05
DOI:
EISSN:
1872-6623
ISSN:
0304-3959
URN:
uuid:2ea054ad-eb74-4d3a-93ef-c4f6b8997190
Source identifiers:
395549
Local pid:
pubs:395549
Language:
English
Keywords:

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