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Identification of the mouse beta'-COP Golgi component as a spermatocyte autoantigen in scleroderma and mapping of its gene Copb2 to mouse chromosome 9.

Abstract:

In an immunological screening of a mouse testicular cDNA library with a human CREST serum we isolated five overlapping cDNA clones encoding the mouse homolog of a Golgi coatomer complex protein (accession number AF043120), designated beta'-COP in bovine and p102 in humans. We generated antibodies against this protein which specifically recognize the Golgi apparatus of mouse spermatocytes. FISH analyses assigned the beta'-COP gene Copb2 to mouse Chromosome 9, region E3-F1. Our results demonstr...

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Publication status:
Published

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Publisher copy:
10.1159/000015467

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Pearlman, RE More by this author
Journal:
Cytogenetics and cell genetics
Volume:
87
Issue:
3-4
Pages:
201-204
Publication date:
1999
DOI:
EISSN:
1424-859X
ISSN:
0301-0171
URN:
uuid:2e9dcfb2-a304-433b-ae66-799c34e3e72b
Source identifiers:
131464
Local pid:
pubs:131464

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