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Serine is the major residue for ADP-ribosylation upon DNA damage

Abstract:

Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that synthesise ADP-ribosylation (ADPr), a reversible modification of proteins that regulates many different cellular processes. Several mammalian PARPs are known to regulate the DNA damage response, but it is not clear which amino acids in proteins are the primary ADPr targets. Previously, we reported that ARH3 reverses the newly discovered type of ADPr (ADPr on serine residues; Ser-ADPr) and developed tools to analyse this modific...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.7554/elife.34334

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0002-5556-5549
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Role:
Author
ORCID:
0000-0001-5315-014X
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0002-5467-5586
More by this author
Role:
Author
ORCID:
0000-0003-0170-7991
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Funding agency for:
Matic, I
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Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
7
Pages:
Article: e34334
Chapter number:
34334
Publication date:
2018-02-26
Acceptance date:
2018-02-23
DOI:
ISSN:
2050-084X
Pubs id:
pubs:828490
URN:
uri:2e982dc2-8d90-4a52-8d58-5575fa213ea3
UUID:
uuid:2e982dc2-8d90-4a52-8d58-5575fa213ea3
Local pid:
pubs:828490

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