Journal article
Serine is the major residue for ADP-ribosylation upon DNA damage
- Abstract:
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Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that synthesise ADP-ribosylation (ADPr), a reversible modification of proteins that regulates many different cellular processes. Several mammalian PARPs are known to regulate the DNA damage response, but it is not clear which amino acids in proteins are the primary ADPr targets. Previously, we reported that ARH3 reverses the newly discovered type of ADPr (ADPr on serine residues; Ser-ADPr) and developed tools to analyse this modific...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.7MB, Terms of use)
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- Publisher copy:
- 10.7554/elife.34334
Authors
Funding
+ Italian Foundation for Cancer Research
More from this funder
Funding agency for:
Palazzo, L
Grant:
14895
Bibliographic Details
- Publisher:
- eLife Sciences Publications
- Journal:
- eLife More from this journal
- Volume:
- 7
- Article number:
- e34334
- Publication date:
- 2018-02-26
- Acceptance date:
- 2018-02-23
- DOI:
- ISSN:
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2050-084X
- Pmid:
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29480802
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:828490
- UUID:
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uuid:2e982dc2-8d90-4a52-8d58-5575fa213ea3
- Local pid:
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pubs:828490
- Source identifiers:
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828490
- Deposit date:
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2018-03-12
Terms of use
- Copyright holder:
- © 2018, Palazzo et al
- Copyright date:
- 2018
- Notes:
- This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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