Journal article
Serine is the major residue for ADP-ribosylation upon DNA damage
- Abstract:
-
Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that synthesise ADP-ribosylation (ADPr), a reversible modification of proteins that regulates many different cellular processes. Several mammalian PARPs are known to regulate the DNA damage response, but it is not clear which amino acids in proteins are the primary ADPr targets. Previously, we reported that ARH3 reverses the newly discovered type of ADPr (ADPr on serine residues; Ser-ADPr) and developed tools to analyse this modific...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Italian Foundation for Cancer Research
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Funding agency for:
Palazzo, L
Grant:
14895
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Bibliographic Details
- Publisher:
- eLife Sciences Publications Publisher's website
- Journal:
- eLife Journal website
- Volume:
- 7
- Article number:
- e34334
- Publication date:
- 2018-02-26
- Acceptance date:
- 2018-02-23
- DOI:
- ISSN:
-
2050-084X
- Pmid:
-
29480802
- Source identifiers:
-
828490
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:828490
- UUID:
-
uuid:2e982dc2-8d90-4a52-8d58-5575fa213ea3
- Local pid:
- pubs:828490
- Deposit date:
- 2018-03-12
Terms of use
- Copyright holder:
- © 2018, Palazzo et al
- Copyright date:
- 2018
- Notes:
- This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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