- Abstract:
-
Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that synthesise ADP-ribosylation (ADPr), a reversible modification of proteins that regulates many different cellular processes. Several mammalian PARPs are known to regulate the DNA damage response, but it is not clear which amino acids in proteins are the primary ADPr targets. Previously, we reported that ARH3 reverses the newly discovered type of ADPr (ADPr on serine residues; Ser-ADPr) and developed tools to analyse this modific...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 2.7MB)
-
- Publisher copy:
- 10.7554/elife.34334
-
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- Publisher:
- eLife Sciences Publications Publisher's website
- Journal:
- eLife Journal website
- Volume:
- 7
- Pages:
- Article: e34334
- Chapter number:
- 34334
- Publication date:
- 2018-02-26
- Acceptance date:
- 2018-02-23
- DOI:
- ISSN:
-
2050-084X
- Pubs id:
-
pubs:828490
- URN:
-
uri:2e982dc2-8d90-4a52-8d58-5575fa213ea3
- UUID:
-
uuid:2e982dc2-8d90-4a52-8d58-5575fa213ea3
- Local pid:
- pubs:828490
- Language:
- English
- Keywords:
- Copyright holder:
- © 2018, Palazzo et al.
- Copyright date:
- 2018
- Notes:
- This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Journal article
Serine is the major residue for ADP-ribosylation upon DNA damage
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