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Journal article

O-glycan sialylation and the structure of the stalk-like region of the T cell co-receptor CD8.

Abstract:

Studies of mucins suggest that the structural effects of O-glycans are restricted to steric interactions between peptide-linked GalNAc residues and adjacent polypeptide residues. It has been proposed, however, that differential O-glycan sialylation alters the structure of the stalk-like region of the T cell co-receptor, CD8, and that this, in turn, modulates ligand binding (Daniels, M. A., Devine, L., Miller, J. D., Moser, J. M., Lukacher, A. E., Altman, J. D., Kavathas, P., Hogquist, K. A., ...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m213056200

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
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Journal:
The Journal of biological chemistry
Volume:
278
Issue:
29
Pages:
27119-27128
Publication date:
2003-07-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:2e7ba293-5ac0-4bec-b8c2-d6339c1775f5
Source identifiers:
12274
Local pid:
pubs:12274

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