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Risk of trachomatous scarring and trichiasis in Gambians varies with SNP haplotypes at the interferon-gamma and interleukin-10 loci.

Abstract:

Experimental evidence implicates interferon gamma (IFNgamma) in protection from and resolution of chlamydial infection. Conversely, interleukin 10 (IL10) is associated with susceptibility and persistence of infection and pathology. We studied genetic variation within the IL10 and IFNgamma loci in relation to the risk of developing severe complications of human ocular Chlamydia trachomatis infection. A total of 651 Gambian subjects with scarring trachoma, of whom 307 also had potentially blind...

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Publication status:
Published

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Publisher copy:
10.1038/sj.gene.6364182

Authors


Natividad, A More by this author
Holland, MJ More by this author
Rockett, K More by this author
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Journal:
Genes and immunity
Volume:
6
Issue:
4
Pages:
332-340
Publication date:
2005-06-05
DOI:
EISSN:
1476-5470
ISSN:
1466-4879
URN:
uuid:2e792c92-807f-4dcf-a1be-da1260d0a950
Source identifiers:
39498
Local pid:
pubs:39498

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