- Abstract:
-
Cyclic ADP-ribose (cADPR) is a second messenger that acts on ryanodine receptors to mobilize Ca(2+). cADPR has a net negative charge at physiological pH making it not passively membrane permeant thereby requiring it to be injected, electroporated or loaded via liposomes. Such membrane impermeance of other charged intracellular messengers (including cyclic AMP, inositol 1,4,5-trisphosphate and nicotinic acid adenine dinucleotide phosphate) and fluorescent dyes (including fura-2 and fluorescein...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.bbrc.2012.01.025
-
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- Journal:
- Biochemical and biophysical research communications
- Volume:
- 418
- Issue:
- 2
- Pages:
- 353-358
- Publication date:
- 2012-02-05
- DOI:
- EISSN:
-
1090-2104
- ISSN:
-
0006-291X
- URN:
-
uuid:2e70b7b1-a5fa-4e46-afd5-14c5c90d18c5
- Source identifiers:
-
246277
- Local pid:
- pubs:246277
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Synthesis and use of cell-permeant cyclic ADP-ribose.
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