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Journal article

Synthesis and use of cell-permeant cyclic ADP-ribose.

Abstract:

Cyclic ADP-ribose (cADPR) is a second messenger that acts on ryanodine receptors to mobilize Ca(2+). cADPR has a net negative charge at physiological pH making it not passively membrane permeant thereby requiring it to be injected, electroporated or loaded via liposomes. Such membrane impermeance of other charged intracellular messengers (including cyclic AMP, inositol 1,4,5-trisphosphate and nicotinic acid adenine dinucleotide phosphate) and fluorescent dyes (including fura-2 and fluorescein...

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Publication status:
Published

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Publisher copy:
10.1016/j.bbrc.2012.01.025

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Journal:
Biochemical and biophysical research communications
Volume:
418
Issue:
2
Pages:
353-358
Publication date:
2012-02-05
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:2e70b7b1-a5fa-4e46-afd5-14c5c90d18c5
Source identifiers:
246277
Local pid:
pubs:246277

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