T cell responses are regulated by the affinity/avidity of the T cell receptor for the MHC/peptide complex, available costimulation and duration of antigenic stimulation. Altered peptide ligands (APLs) are usually recognized with a reduced affinity/avidity by the T cell receptor and are often able to only partially activate T cells in vitro or may even function as antagonists. Here we assessed the ability of APLs derived from peptide p33 of lymphocytic choriomeningitis virus (LCMV) to mediate ...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
Limited in vivo reactivity of polyclonal effector cytotoxic T cells towards altered peptide ligands.
If you are the owner of this record, you can report an update to it here: Report update to this record