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Limited in vivo reactivity of polyclonal effector cytotoxic T cells towards altered peptide ligands.

Abstract:

T cell responses are regulated by the affinity/avidity of the T cell receptor for the MHC/peptide complex, available costimulation and duration of antigenic stimulation. Altered peptide ligands (APLs) are usually recognized with a reduced affinity/avidity by the T cell receptor and are often able to only partially activate T cells in vitro or may even function as antagonists. Here we assessed the ability of APLs derived from peptide p33 of lymphocytic choriomeningitis virus (LCMV) to mediate ...

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Publication status:
Published

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Authors


Bättig, P More by this author
Gallimore, A More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Journal:
Microbes and infection / Institut Pasteur
Volume:
7
Issue:
4
Pages:
729-737
Publication date:
2005-04-05
DOI:
EISSN:
1769-714X
ISSN:
1286-4579
URN:
uuid:2e6f6c7d-e1b2-425d-8b89-57bcbe7892e3
Source identifiers:
469732
Local pid:
pubs:469732

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