Thesis
Autophagy in hematopoiesis and acute myeloid leukemia
- Abstract:
-
Acute myeloid leukemia (AML) develops following oncogenic alterations to hematopoietic stem (HSC) and progenitor cells (HSPCs) in the bone marrow, resulting in dysregulated proliferation of immature myeloid progenitors that interferes with normal hematopoiesis. Understanding the mechanisms of HSPC protection against damage and excessive division, and how these pathways are altered during leukemic progression, is vital for establishing effective therapies. Here, we show that autophagy, a ly...
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Authors
Contributors
+ Simon, A
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Supervisor
Funding
Bibliographic Details
- Publication date:
- 2014
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:2e66c5c3-4774-44d1-8345-d0dc827da16d
- Local pid:
- ora:9727
- Deposit date:
- 2015-01-13
Terms of use
- Copyright holder:
- Watson, A
- Copyright date:
- 2014
- Notes:
- This thesis is not currently available in ORA.
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