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Immunodrugs: breaking B- but not T-cell tolerance with therapeutic anticytokine vaccines.

Abstract:

Pathology in most chronic inflammatory diseases is characterized by an imbalance in cytokine expression. Targeting cytokines with monoclonal antibodies has proven to be a highly effective treatment. However, monoclonal antibody therapy has disadvantages such as high production costs, generation of antimonoclonal antibodies and the inconvenience of frequent injections. Therapeutic vaccines have the potential to overcome these limitations. The aim of active vaccination is to induce B-cell respo...

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Publication status:
Published

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Publisher copy:
10.2217/imt.10.30

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Journal:
Immunotherapy
Volume:
2
Issue:
4
Pages:
561-574
Publication date:
2010-07-05
DOI:
EISSN:
1750-7448
ISSN:
1750-743X
URN:
uuid:2e518330-912c-4d2c-a234-af9c587cf716
Source identifiers:
422338
Local pid:
pubs:422338

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