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Aerosol delivery of a candidate universal influenza vaccine reduces viral load in pigs challenged with pandemic H1N1 virus

Abstract:

Influenza A viruses are a major health threat to livestock and humans, causing considerable mortality, morbidity, and economic loss. Current inactivated influenza vaccines are strain specific and new vaccines need to be produced at frequent intervals to combat newly arising influenza virus strains, so that a universal vaccine is highly desirable. We show that pandemic H1N1 influenza virus in which the hemagglutinin signal sequence has been suppressed (S-FLU), when administered to pigs by aero...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.4049/jimmunol.1502632

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Publisher:
American Association of Immunologists Publisher's website
Journal:
Journal of Immunology Journal website
Volume:
196
Issue:
12
Pages:
5014-5023
Publication date:
2016-05-06
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:2e389e52-3153-4c1e-b695-32e4725861a6
Source identifiers:
623384
Local pid:
pubs:623384
Language:
English

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