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Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor.

Abstract:

The retinoblastoma tumor suppressor protein pRb is a key regulator of cell cycle progression and mediator of the DNA damage response. Lysine methylation at K810, which occurs within a critical Cdk phosphorylation motif, holds pRb in the hypophosphorylated growth-suppressing state. We show here that methyl K810 is read by the tandem tudor domain containing tumor protein p53 binding protein 1 (53BP1). Structural elucidation of 53BP1 in complex with a methylated K810 pRb peptide emphasized the r...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1403737111

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Publisher:
National Academy of Sciences
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
111
Issue:
31
Pages:
11341-11346
Publication date:
2014-08-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:2e34d6cb-ab72-4f1b-b81f-4c2f264c7b29
Source identifiers:
477014
Local pid:
pubs:477014

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