Journal article
Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor.
- Abstract:
-
The retinoblastoma tumor suppressor protein pRb is a key regulator of cell cycle progression and mediator of the DNA damage response. Lysine methylation at K810, which occurs within a critical Cdk phosphorylation motif, holds pRb in the hypophosphorylated growth-suppressing state. We show here that methyl K810 is read by the tandem tudor domain containing tumor protein p53 binding protein 1 (53BP1). Structural elucidation of 53BP1 in complex with a methylated K810 pRb peptide emphasized the r...
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- Publication status:
- Published
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- Publisher copy:
- 10.1073/pnas.1403737111
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Authors
Bibliographic Details
- Publisher:
- National Academy of Sciences
- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 111
- Issue:
- 31
- Pages:
- 11341-11346
- Publication date:
- 2014-08-01
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- Source identifiers:
-
477014
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:477014
- UUID:
-
uuid:2e34d6cb-ab72-4f1b-b81f-4c2f264c7b29
- Local pid:
- pubs:477014
- Deposit date:
- 2014-08-06
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- Copyright date:
- 2014
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