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Lectin complement pathway gene profile of the donor and recipient does not influence graft outcome after kidney transplantation

Abstract:

In kidney transplantation, complement activation was found to be induced by donor brain death, renal ischemia-reperfusion injury and allograft rejection. There are three known pathways of complement activation: the classical, lectin and the alternative pathway. The lectin complement pathway can be activated upon pattern recognition by mannan binding lectin (MBL) or ficolins (FCN). Single nucleotide polymorphisms (SNPs) in the genes encoding the lectin pathway proteins determine their function...

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Authors


Leuvenink, HG More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Reznichenko, A More by this author
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Journal:
Molecular Immunology
Volume:
50
Issue:
1-2
Pages:
1-8
Publication date:
2012-02-05
DOI:
EISSN:
1872-9142
ISSN:
0161-5890
URN:
uuid:2e28f635-1a0d-4fd4-8362-bd5b40ad5207
Source identifiers:
316766
Local pid:
pubs:316766

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