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Journal article

Open-label randomized trial of oral trimethoprim-sulfamethoxazole, doxycycline, and chloramphenicol compared with trimethoprim-sulfamethoxazole and doxycycline for maintenance therapy of melioidosis.

Abstract:

Melioidosis (infection caused by Burkholderia pseudomallei) requires a prolonged course of oral antibiotics following initial intravenous therapy to reduce the risk of relapse after cessation of treatment. The current recommendation is a four-drug regimen (trimethoprim [TMP], sulfamethoxazole [SMX], doxycycline, and chloramphenicol) and a total treatment time of 12 to 20 weeks. Drug side effects are common; the aim of this study was to compare the efficacy and tolerance of the four-drug regim...

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Publication status:
Published

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Journal:
Antimicrobial agents and chemotherapy
Volume:
49
Issue:
10
Pages:
4020-4025
Publication date:
2005-10-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:2e25222a-c2fb-4e8e-9df4-aa211324b149
Source identifiers:
26591
Local pid:
pubs:26591

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