Journal article
Expression of CDKN1C in the bone marrow of patients with myelodysplastic syndrome and secondary acute myeloid leukemia is associated with poor survival after conventional chemotherapy
- Abstract:
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We tested the hypothesis, that proliferative activity of hematopoietic stem cells has impact on survival in newly diagnosed patients with myelodysplastic syndrome (MDS) and secondary acute myeloid leukemia (AML). RNA expression profiles of CD34(+) cells were analyzed in 125 MDS patients and compared to healthy controls. Prognostic impact on overall survival (OS) of mRNA proliferation signatures established for solid tumor cells was analyzed retrospectively. For validation on the protein level...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Accepted manuscript, pptx, 1.3MB)
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(Accepted manuscript, pdf, 184.9KB)
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(Accepted manuscript, pptx, 122.9KB)
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- Publisher copy:
- 10.1002/ijc.30181
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Authors
Funding
B.L.U.T. e.V.
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Celgene GmbH
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Bloodwise
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Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- International Journal of Cancer Journal website
- Volume:
- 139
- Issue:
- 6
- Pages:
- 1402–1413
- Publication date:
- 2016-06-03
- Acceptance date:
- 2016-04-25
- DOI:
- EISSN:
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1097-0215
- ISSN:
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0020-7136
- Source identifiers:
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622964
Item Description
Terms of use
- Copyright holder:
- Union for International Cancer Control
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 UICC. This is the accepted manuscript version of the article. The final version is available online from Wiley at: https://doi.org/10.1002/ijc.30181
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