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Journal article

Expression of CDKN1C in the bone marrow of patients with myelodysplastic syndrome and secondary acute myeloid leukemia is associated with poor survival after conventional chemotherapy

Abstract:

We tested the hypothesis, that proliferative activity of hematopoietic stem cells has impact on survival in newly diagnosed patients with myelodysplastic syndrome (MDS) and secondary acute myeloid leukemia (AML). RNA expression profiles of CD34(+) cells were analyzed in 125 MDS patients and compared to healthy controls. Prognostic impact on overall survival (OS) of mRNA proliferation signatures established for solid tumor cells was analyzed retrospectively. For validation on the protein level...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/ijc.30181

Authors


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B.L.U.T. e.V. More from this funder
Celgene GmbH More from this funder
Publisher:
Wiley Publisher's website
Journal:
International Journal of Cancer Journal website
Volume:
139
Issue:
6
Pages:
1402–1413
Publication date:
2016-06-03
DOI:
EISSN:
1097-0215
ISSN:
0020-7136
URN:
uuid:2e0edf58-fcec-4e0b-b25d-ddc6a542f9d7
Source identifiers:
622964
Local pid:
pubs:622964
Paper number:
6
Language:
English
Keywords:

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