- Abstract:
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We tested the hypothesis, that proliferative activity of hematopoietic stem cells has impact on survival in newly diagnosed patients with myelodysplastic syndrome (MDS) and secondary acute myeloid leukemia (AML). RNA expression profiles of CD34(+) cells were analyzed in 125 MDS patients and compared to healthy controls. Prognostic impact on overall survival (OS) of mRNA proliferation signatures established for solid tumor cells was analyzed retrospectively. For validation on the protein level...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Files:
-
-
(pdf, 184.9KB)
-
(pptx, 1.3MB)
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(pptx, 122.9KB)
-
- Publisher copy:
- 10.1002/ijc.30181
-
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- Publisher:
- Wiley Publisher's website
- Journal:
- International Journal of Cancer Journal website
- Volume:
- 139
- Issue:
- 6
- Pages:
- 1402–1413
- Publication date:
- 2016-06-03
- DOI:
- EISSN:
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1097-0215
- ISSN:
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0020-7136
- URN:
-
uuid:2e0edf58-fcec-4e0b-b25d-ddc6a542f9d7
- Source identifiers:
-
622964
- Local pid:
- pubs:622964
- Paper number:
- 6
- Copyright holder:
- Union for International Cancer Control
- Copyright date:
- 2016
- Notes:
-
Copyright © 2016 UICC. This is the accepted manuscript version of the article. The final version is available online from Wiley at: https://doi.org/10.1002/ijc.30181
Journal article
Expression of CDKN1C in the bone marrow of patients with myelodysplastic syndrome and secondary acute myeloid leukemia is associated with poor survival after conventional chemotherapy
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B.L.U.T. e.V.
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Celgene GmbH
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Bloodwise
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