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Tyrosine-free amino acid mixture attenuates amphetamine-induced displacement of [11C]raclopride in striatum in vivo: a rat PET study.

Abstract:

Previous neurochemical and behavioural studies show that tyrosine depletion using a nutritionally balanced tyrosine-free amino acid mixture attenuates the dopamine-releasing and psychostimulant properties of amphetamine. Here we investigate the effect of a tyrosine-free amino acid mixture on striatal binding of [(11)C]raclopride, and amphetamine-induced [(11)C]raclopride displacement, using positron emission tomography in the rat. Rats were scanned for 60 min after an i.v. injection of approx...

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Publication status:
Published

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Publisher copy:
10.1002/syn.10285

Authors


Le Masurier, M More by this author
Houston, G More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
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Journal:
Synapse (New York, N.Y.)
Volume:
51
Issue:
2
Pages:
151-157
Publication date:
2004-02-05
DOI:
EISSN:
1098-2396
ISSN:
0887-4476
URN:
uuid:2dffd90d-f5ee-41bf-a2f7-b4ffb8d54867
Source identifiers:
139536
Local pid:
pubs:139536

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