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Proteoglycan synthesis in the intervertebral disk nucleus: The role of extracellular osmolality

Abstract:

Proteoglycans, through their polyelectrolyte properties, regulate the ionic composition and hence the osmotic pressure of the extracellular matrix. We measured the change in [35S]sulfate incorporation, a marker of proteoglycan synthesis, in explants of bovine nucleus pulposus. During incubation, nucleus slices swelled 200% and proteoglycans leached from the matrix, so that extracellular osmolality fell from 420-450 to ~300 mosmol/kgH2O. When in vivo extracellular osmolality was maintained eit...

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Journal:
American Journal of Physiology - Cell Physiology
Volume:
272
Issue:
5 41-5
Publication date:
1997-01-01
ISSN:
0363-6143
URN:
uuid:2dfcc590-dd94-4d35-a722-6882073eb3f2
Source identifiers:
430633
Local pid:
pubs:430633

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