- Abstract:
-
A commonly occurring polymorphic variant of the human 5-hydroxytryptamine (5-HT) transporter (5-HTT) gene that increases 5-HTT expression has been associated with reduced anxiety levels in human volunteer and patient populations. However, it is not known whether this linkage between genotype and anxiety relates to variation in 5-HTT expression and consequent changes in 5-HT transmission. Here we test this hypothesis by measuring the neurochemical and behavioral characteristics of a mouse gene...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1523/jneurosci.5356-05.2006
-
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- Journal:
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- Volume:
- 26
- Issue:
- 35
- Pages:
- 8955-8964
- Publication date:
- 2006-08-05
- DOI:
- EISSN:
-
1529-2401
- ISSN:
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0270-6474
- URN:
-
uuid:2df04c05-3637-44f7-84f1-4a49920597d9
- Source identifiers:
-
4927
- Local pid:
- pubs:4927
- Copyright date:
- 2006
Journal article
Increased expression of the 5-HT transporter confers a low-anxiety phenotype linked to decreased 5-HT transmission.
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