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Increased expression of the 5-HT transporter confers a low-anxiety phenotype linked to decreased 5-HT transmission.

Abstract:

A commonly occurring polymorphic variant of the human 5-hydroxytryptamine (5-HT) transporter (5-HTT) gene that increases 5-HTT expression has been associated with reduced anxiety levels in human volunteer and patient populations. However, it is not known whether this linkage between genotype and anxiety relates to variation in 5-HTT expression and consequent changes in 5-HT transmission. Here we test this hypothesis by measuring the neurochemical and behavioral characteristics of a mouse gene...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
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Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
26
Issue:
35
Pages:
8955-8964
Publication date:
2006-08-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:2df04c05-3637-44f7-84f1-4a49920597d9
Source identifiers:
4927
Local pid:
pubs:4927

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