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The isolated, buffer-perfused ferret heart: a new model for the study of cardiac physiology and metabolism.

Abstract:

The isolated, buffer-perfused ferret heart is a new model for the study of cardiac physiology and metabolism. Compared to the more commonly used isolated heart preparation, the rat heart, the ferret has a lower rate-pressure product due to lower heart rate, a remarkably low coronary flow and almost complete oxygen extraction. The ferret heart remains in stable haemodynamic and metabolic conditions for a longer period of time than the rat heart. ATP contents of the two species are similar, but...

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Publisher copy:
10.1258/002367791780809995

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Ingwall, JS More by this author
Journal:
Laboratory animals
Volume:
25
Issue:
4
Pages:
348-353
Publication date:
1991-10-05
DOI:
EISSN:
1758-1117
ISSN:
0023-6772
URN:
uuid:2deb9a71-9700-4040-9c74-a5d1fd116c7d
Source identifiers:
441434
Local pid:
pubs:441434

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