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Lysozyme is an inducible marker of macrophage activation in murine tissues as demonstrated by in situ hybridization.

Abstract:

This study demonstrates the induction of lysozyme mRNA expression in situ in tissue macrophages (M phi) of mice following in vivo stimulation. The resting resident tissue M phi of most tissues do not contain enough lysozyme mRNA to be detected by in situ hybridization using 35S-labeled RNA probes. Following Bacille Calmette Guerin or Plasmodium yoelli infection, however, M phi recruited to liver and spleen hybridize strongly to the lysozyme probe. Within 24 h of infection, cells found in the ...

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Publication status:
Published

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Publisher copy:
10.1084/jem.174.5.1049

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Medicine Division, Clinical Medicine
Role:
Author
Journal:
The Journal of experimental medicine
Volume:
174
Issue:
5
Pages:
1049-1058
Publication date:
1991-11-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:2ddc86bb-1199-4922-96e9-98c4ac31c7e0
Source identifiers:
30316
Local pid:
pubs:30316

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