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Thermodynamic influences on the fidelity of iron-sulphur cluster formation in proteins.

Abstract:
In an organism, two thermodynamic factors are important in ensuring that homometallic [4Fe-4S] cubane clusters are formed in preference to clusters containing heterometals such as Zn or Cu. These are the electronic resonance stabilisation, which boosts the binding of Fe(II) within an Fe-S cluster relative to its normally low position in the Irving-Williams order, and attenuation of the cytoplasmic concentrations of competing metals such as Zn or Cu by specific ligands.
Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Inorganic Chemistry
Role:
Author
Journal:
FEBS letters
Volume:
451
Issue:
2
Pages:
91-94
Publication date:
1999-05-05
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:2dd5c0b7-08cf-4675-9895-2669f03a787b
Source identifiers:
31502
Local pid:
pubs:31502

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