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Evidence for differential expression of CD45 isoforms by precursors for memory-dependent and independent cytotoxic responses: human CD8 memory CTLp selectively express CD45RO (UCHL1).

Abstract:

On the basis of differential CD45 expression, human T cells can be separated into approximately reciprocal populations. The mAb UCHL1 detects a 180 kd molecular mass isoform, CD45R0. The CD45RA cluster of mAbs reacts with CD45 isoforms of 205 and 220 kd molecular mass. These reagents subdivide both CD4 and CD8 T cell populations. CD4 T cells that proliferate in response to memory-dependent (recall) antigens have been shown to selectively express CD45R0. We extend these observations to a model...

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Publisher copy:
10.1093/intimm/1.4.450

Authors


Merkenschlager, M More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Journal:
International immunology
Volume:
1
Issue:
4
Pages:
450-459
Publication date:
1989
DOI:
EISSN:
1460-2377
ISSN:
0953-8178
URN:
uuid:2dc4f365-5a93-4068-8529-801a5e048128
Source identifiers:
35195
Local pid:
pubs:35195

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