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Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs

Abstract:

p21-activated kinases have been classified into two groups based on their domain architecture. Group II PAKs (PAK4-6) regulate a wide variety of cellular functions, and PAK deregulation has been linked to tumor development. Structural comparison of five high-resolution structures comprising all active, monophosphorylated group II catalytic domains revealed a surprising degree of domain plasticity, including a number of catalytically productive and nonproductive conformers. Rearrangements of h...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.str.2007.01.001

Authors


Eswaran, Jeyanthy More by this author
Lee, Wen Hwa More by this author
Debreczeni, Judit E More by this author
Filippakopoulos, Panagis More by this author
Turnbull, Andrew More by this author
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Publisher:
Cell Press Publisher's website
Journal:
Structure Journal website
Volume:
15
Issue:
2
Pages:
201-213
Publication date:
2007
DOI:
ISSN:
0969-2126
URN:
uuid:2dbb46ee-6e05-4d4e-b23b-84b31efe7a0a
Local pid:
SGC:17292838

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