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Induction of bystander T cell proliferation by viruses and type I interferon in vivo.

Abstract:

T cell proliferation in vivo is presumed to reflect a T cell receptor (TCR)-mediated polyclonal response directed to various environmental antigens. However, the massive proliferation of T cells seen in viral infections is suggestive of a bystander reaction driven by cytokines instead of the TCR. In mice, T cell proliferation in viral infections preferentially affected the CD44hi subset of CD8+ cells and was mimicked by injection of polyinosinic-polycytidylic acid [poly(I:C)], an inducer of t...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Journal:
Science (New York, N.Y.)
Volume:
272
Issue:
5270
Pages:
1947-1950
Publication date:
1996-06-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:2db87459-2242-471a-a9b2-85d3c75af571
Source identifiers:
35927
Local pid:
pubs:35927

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