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Journal article

Recruitment of myeloid cells to the tumor microenvironment supports liver metastasis.

Abstract:
Tumor-infiltrating immune cells play important roles in metastasis. We have recently revealed the recruitment of a specific myeloid cell subset (CD11b/Gr1(mid)) to hepatic metastases. Such a recruitment relies on CCL2/CCR2 signaling and acts to sustain metastatic growth. A similar cell subset was identified in patients bearing hepatic metastases of colorectal cancer, highlighting the potential therapeutic relevance of our findings.
Publication status:
Published

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Publisher copy:
10.4161/onci.23187

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Journal:
Oncoimmunology
Volume:
2
Issue:
3
Pages:
e23187
Publication date:
2013-03-05
DOI:
EISSN:
2162-402X
ISSN:
2162-4011
URN:
uuid:2db31d19-d762-4d52-a659-dd5da50abd6d
Source identifiers:
407665
Local pid:
pubs:407665

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