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Development of an in vitro assay and demonstration of Plasmodium berghei liver-stage inhibition by TRAP-specific CD8+ T cells

Abstract:

The development of an efficacious vaccine against the Plasmodium parasite remains a top priority. Previous research has demonstrated the ability of a prime-boost virally vectored sub-unit vaccination regimen, delivering the liver-stage expressed malaria antigen TRAP, to produce high levels of antigen-specific T cells. The liver-stage of malaria is the main target of T cell-mediated immunity, yet a major challenge in assessing new T cell inducing vaccines has been the lack of a suitable pre-cl...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0119880

Authors


Longley, RJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Strategic
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Jenner Institute
Publisher:
The Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
10
Issue:
3
Pages:
e0119880
Publication date:
2015-01-05
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:2db2e5a8-e34d-41ee-84ae-1783b807f4b1
Source identifiers:
516939
Local pid:
pubs:516939
Language:
English

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