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Journal article

The immunoglobulin E-allergen interaction: a target for therapy of type I allergic diseases.

Abstract:
The interaction of immunoglobulin E and otherwise harmless antigens (allergens) leads in sensitized individuals through effector cell activation to the immediate induction of a cascade of inflammatory reactions, the hallmark of type I allergy. Recently, the molecular and structural characterization of allergens, specific IgE antibodies and their epitopes has made rapid progress. Here we discuss active and passive strategies for therapy of type I allergy, which are based on interfering with the IgE-allergen interaction.
Publication status:
Published

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Publisher copy:
10.1159/000023942

Authors


Valenta, R More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Steinberger, P More by this author
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Journal:
International archives of allergy and immunology
Volume:
116
Issue:
3
Pages:
167-176
Publication date:
1998-07-05
DOI:
EISSN:
1423-0097
ISSN:
1018-2438
URN:
uuid:2da95989-65d1-4d85-aed5-847c35452ce9
Source identifiers:
69750
Local pid:
pubs:69750

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