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Mathematical modelling of fibre-enhanced perfusion inside a tissue-engineering bioreactor.

Abstract:

We develop a simple mathematical model for forced flow of culture medium through a porous scaffold in a tissue-engineering bioreactor. Porous-walled hollow fibres penetrate the scaffold and act as additional sources of culture medium. The model, based on Darcy's law, is used to examine the nutrient and shear-stress distributions throughout the scaffold. We consider several configurations of fibres and inlet and outlet pipes. Compared with a numerical solution of the full Navier-Stokes equatio...

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Publication status:
Published

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Publisher copy:
10.1016/j.jtbi.2008.10.013

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Journal:
Journal of theoretical biology
Volume:
256
Issue:
4
Pages:
533-546
Publication date:
2009-02-05
DOI:
EISSN:
1095-8541
ISSN:
0022-5193
URN:
uuid:2da3a45b-51c4-4637-8735-08c0128b7057
Source identifiers:
2917
Local pid:
pubs:2917

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