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Overexpressing centriole-replication proteins in vivo induces centriole overduplication and de novo formation.

Abstract:

BACKGROUND: Centrosomes have important roles in many aspects of cell organization, and aberrations in their number and function are associated with various diseases, including cancer. Centrosomes consist of a pair of centrioles surrounded by a pericentriolar matrix (PCM), and their replication is tightly regulated. Here, we investigate the effects of overexpressing the three proteins known to be required for centriole replication in Drosophila-DSas-6, DSas-4, and Sak. RESULTS: By directly ob...

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Publication status:
Published

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Publisher copy:
10.1016/j.cub.2007.04.036

Authors


Stevens, NR More by this author
Journal:
Current biology : CB
Volume:
17
Issue:
10
Pages:
834-843
Publication date:
2007-05-05
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
URN:
uuid:2d92d64f-1f16-4b40-ac69-f5ce2c20d6a3
Source identifiers:
223387
Local pid:
pubs:223387

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