p53 function is of critical importance in suppressing human cancer formation, highlighted by the fact that the majority of human tumors harbor compromised p53 activity. In normal cells, p53 is held at low levels in a latent form and cellular stress results in the rapid stabilization of p53. Mdm2 mediates ubiquitin-dependent degradation of p53 which plays a key role in maintaining cellular p53 levels. Ubiquitination was, until recently, considered a straightforward system involved in p53 degra...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
p53 ubiquitination by Mdm2: a never ending tail?
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record