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Journal article

p53 ubiquitination by Mdm2: a never ending tail?

Abstract:

p53 function is of critical importance in suppressing human cancer formation, highlighted by the fact that the majority of human tumors harbor compromised p53 activity. In normal cells, p53 is held at low levels in a latent form and cellular stress results in the rapid stabilization of p53. Mdm2 mediates ubiquitin-dependent degradation of p53 which plays a key role in maintaining cellular p53 levels. Ubiquitination was, until recently, considered a straightforward system involved in p53 degra...

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Publication status:
Published

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Journal:
DNA repair
Volume:
8
Issue:
4
Pages:
483-490
Publication date:
2009-04-05
DOI:
EISSN:
1568-7856
ISSN:
1568-7864
URN:
uuid:2d603698-c6e4-4090-a710-b3185b66c580
Source identifiers:
261151
Local pid:
pubs:261151

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