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MIG (CXCL9) is a more sensitive measure than IFN-gamma of vaccine induced T-cell responses in volunteers receiving investigated malaria vaccines.

Abstract:

For many years the IFN-gamma ex vivo ELISPOT has been a major assay for assessing human T-cell responses generated by malaria vaccines. The ELISPOT assay is a sensitive assay, but an imperfect correlate of protection against malaria. Monokine induced by gamma (MIG), or CXCL9, is a chemokine induced by IFN-gamma and has the potential to provide amplification of the IFN-gamma signal. MIG secretion could provide a measure of bio-active IFN-gamma and a functional IFN-gamma signalling pathway. We ...

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Publication status:
Published

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Publisher copy:
10.1016/j.jim.2008.09.021

Authors


Berthoud, TK More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Journal:
Journal of immunological methods
Volume:
340
Issue:
1
Pages:
33-41
Publication date:
2009-01-05
DOI:
EISSN:
1872-7905
ISSN:
0022-1759
URN:
uuid:2d4bfa85-161d-4d82-ae12-8df797c51d8e
Source identifiers:
34439
Local pid:
pubs:34439

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