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Dimerization of MT1-MMP during cellular invasion detected by fluorescence resonance energy transfer.

Abstract:

Homodimerization of the membrane-bound collagenase MT1-MMP [membrane-type 1 MMP (matrix metalloproteinase)] is crucial for its collagenolytic activity. However, it is not clear whether this dimerization is regulated during cellular invasion into three-dimensional collagen matrices. To address this question, we established a fluorescence resonance energy transfer system to detect MT1-MMP dimerization and analysed the process in cells invading through three-dimensional collagen. Our data indica...

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Publication status:
Published

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Publisher copy:
10.1042/bj20110424

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
The Biochemical journal
Volume:
440
Issue:
3
Pages:
319-326
Publication date:
2011-12-05
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:2d4a9a06-137d-43e6-9812-09a9e512804a
Source identifiers:
224529
Local pid:
pubs:224529

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