Journal article
Dimerization of MT1-MMP during cellular invasion detected by fluorescence resonance energy transfer.
- Abstract:
-
Homodimerization of the membrane-bound collagenase MT1-MMP [membrane-type 1 MMP (matrix metalloproteinase)] is crucial for its collagenolytic activity. However, it is not clear whether this dimerization is regulated during cellular invasion into three-dimensional collagen matrices. To address this question, we established a fluorescence resonance energy transfer system to detect MT1-MMP dimerization and analysed the process in cells invading through three-dimensional collagen. Our data indica...
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- Publication status:
- Published
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- Publisher copy:
- 10.1042/bj20110424
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Authors
Bibliographic Details
- Journal:
- Biochemical journal
- Volume:
- 440
- Issue:
- 3
- Pages:
- 319-326
- Publication date:
- 2011-12-01
- DOI:
- EISSN:
-
1470-8728
- ISSN:
-
0264-6021
- Source identifiers:
-
224529
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:224529
- UUID:
-
uuid:2d4a9a06-137d-43e6-9812-09a9e512804a
- Local pid:
- pubs:224529
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2011
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