Journal article icon

Journal article

Cooperation of gastric mononuclear phagocytes with Helicobacter pylori during colonization

Abstract:

Helicobacter pylori, the dominant member of the human gastric microbiota, elicits immunoregulatory responses implicated in protective versus pathological outcomes. To evaluate the role of macrophages during infection, we employed a system with a shifted proinflammatory macrophage phenotype by deleting PPARγ in myeloid cells and found a 5- to 10-fold decrease in gastric bacterial loads. Higher levels of colonization in wild-type mice were associated with increased presence of mononuclear phago...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.4049/jimmunol.1601902

Authors


More by this author
Role:
Author
ORCID:
0000-0002-5787-8055
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Tropical Medicine
Role:
Author
ORCID:
0000-0003-0867-2867
Expand authors...
Publisher:
American Association of Immunologists Publisher's website
Journal:
Journal of Immunology Journal website
Volume:
198
Issue:
8
Pages:
3195-3204
Publication date:
2017-04-03
Acceptance date:
2017-02-08
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Pubs id:
pubs:895749
URN:
uri:2d48b4a1-599f-470d-976c-02a35ad91448
UUID:
uuid:2d48b4a1-599f-470d-976c-02a35ad91448
Local pid:
pubs:895749
Language:
English

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP