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A mathematical model for a new mechanism of phenotypic variation in malaria.

Abstract:

The Py235 merozoite rhoptry protein of the rodent malaria agent Plasmodium (yoelii) yoeli is encoded by the Py235 multigene family whose members are transcribed during the parasite's asexual life-cycle in a fashion where single schizonts subsequently give rise to sets of merozoites containing distinct Py235 transcripts. Homologues of Py235 are found in other malaria species, and antibodies to both Py235 and P. falciparum homologues inhibit merozoite invasion, suggesting a unique survival stra...

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Publication status:
Published

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Publisher copy:
10.1017/s0031182005007481

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Al-Bader, R More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Journal:
Parasitology
Volume:
131
Issue:
Pt 2
Pages:
151-159
Publication date:
2005-08-05
DOI:
EISSN:
1469-8161
ISSN:
0031-1820
URN:
uuid:2d3df57c-6afc-48e3-a857-516b66646aa9
Source identifiers:
209535
Local pid:
pubs:209535

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