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Cryo electron tomography of herpes simplex virus during axonal transport and secondary envelopment in primary neurons.

Abstract:

During herpes simplex virus 1 (HSV1) egress in neurons, viral particles travel from the neuronal cell body along the axon towards the synapse. Whether HSV1 particles are transported as enveloped virions as proposed by the 'married' model or as non-enveloped capsids suggested by the 'separate' model is controversial. Specific viral proteins may form a recruitment platform for microtubule motors that catalyze such transport. However, their subviral location has remained elusive. Here we establi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.1002406

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Institution:
University of Oxford
Role:
Author
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Funding agency for:
Huiskonen, JT
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Funding agency for:
Grünewald, K
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Funding agency for:
Grünewald, K
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS pathogens Journal website
Volume:
7
Issue:
12
Pages:
e1002406
Publication date:
2011-12-05
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
URN:
uuid:2d31358a-9191-42a5-9049-0d7eec202700
Source identifiers:
222327
Local pid:
pubs:222327

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