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Mcm2, Geminin, and KI67 define proliferative state and are prognostic markers in renal cell carcinoma.

Abstract:

PURPOSE: The origin licensing factors minichromosome maintenance 2 (Mcm2) and Geminin have recently been identified as critical regulators of growth and differentiation. Here we have investigated the regulation of these licensing factors together with Ki67 to further elucidate the cell cycle kinetics of renal cell carcinoma (RCC). Furthermore, we have examined the role of Ki67, Mcm2, and Geminin in disease-free survival after nephrectomy in patients with localized RCC. EXPERIMENTAL DESIGN: T...

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Authors


Dudderidge, TJ More by this author
Stoeber, K More by this author
Atkinson, G More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences
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Journal:
Clinical cancer research : an official journal of the American Association for Cancer Research
Volume:
11
Issue:
7
Pages:
2510-2517
Publication date:
2005-04-05
DOI:
EISSN:
1557-3265
ISSN:
1078-0432
URN:
uuid:2d2d3ed2-a076-4f9f-b073-b235b067438c
Source identifiers:
387996
Local pid:
pubs:387996

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