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miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis.

Abstract:

BACKGROUND: Clear cell renal cancer frequently harbours von Hippel-Lindau (VHL) gene mutations, leading to stabilisation of the hypoxia-inducible factors (HIFs) and expression of their target genes. We investigated HIF-1 and HIF-2 in the regulation of microRNA-210 (miR-210), and its clinical relevance in renal tumours. METHODS: RCC4 and 786-O renal cancer cell lines transfected with either an empty vector or functional VHL and incubated in normoxia or hypoxia were examined for miR-210 express...

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Publication status:
Published

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Publisher copy:
10.1038/bjc.2013.56

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, CCMP
Role:
Author
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Journal:
British journal of cancer
Volume:
108
Issue:
5
Pages:
1133-1142
Publication date:
2013-03-05
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
URN:
uuid:2d26976a-dd42-42a7-b64a-d6ed60a3dc1c
Source identifiers:
387211
Local pid:
pubs:387211

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