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Journal article

Impact of isolated germline JAK2V617I mutation on human hematopoiesis.

Abstract:

The association between somatic JAK2 mutation and myeloproliferative neoplasms (MPNs) is now well established. However, because JAK2 mutations are associated with heterogeneous clinical phenotypes and often occur as secondary genetic events, some aspects of JAK2 mutation biology remain to be understood. We recently described a germline JAK2V617I mutation in a family with hereditary thrombocytosis and herein characterize the hematopoietic and signaling impact of JAK2V617I. Through targeted seq...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Role:
Author
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Journal:
Blood
Volume:
121
Issue:
20
Pages:
4156-4165
Publication date:
2013-05-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:2d21ab33-f03b-4d0c-8eeb-f20aa678bf87
Source identifiers:
390831
Local pid:
pubs:390831

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