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Journal article

Fev regulates hematopoietic stem cell development via ERK signaling.

Abstract:

Reprogramming of somatic cells to desired cell types holds great promise in regenerative medicine. However, production of transplantable hematopoietic stem cells (HSCs) in vitro by defined factors has not yet been achieved. Therefore, it is critical to fully understand the molecular mechanisms of HSC development in vivo. Here, we show that Fev, an ETS transcription factor, is a pivotal regulator of HSC development in vertebrates. In fev-deficient zebrafish embryos, the first definitive HSC po...

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Publication status:
Published

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Journal:
Blood
Volume:
122
Issue:
3
Pages:
367-375
Publication date:
2013-07-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:2d206e51-f4e0-49d6-8519-5ee27b5811fe
Source identifiers:
395950
Local pid:
pubs:395950

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