Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases.

Journal article

2-Oxoglutarate (2OG) and ferrous iron dependent oxygenases catalyze two-electron oxidations of a range of small and large molecule substrates, including proteins/peptides/amino acids, nucleic acids/bases, and lipids, as well as natural products including antibiotics and signaling molecules. 2OG oxygenases employ variations of a core double-stranded β-helix (DSBH; a.k.a. jelly-roll, cupin or jumonji C (JmjC)) fold to enable binding of Fe(II) and 2OG in a subfamily conserved manner. The topolog...

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Authors: Aik, W; McDonough, M; Thalhammer, A; Chowdhury, R; Schofield, C

• Publication status: Published
• Journal: Current opinion in structural biology
• Volume: 22
• Issue: 6
• Pages: 691-700
• Publication date: 2012-12-01
• DOI: 10.1016/j.sbi.2012.10.001
• EISSN: 1879-033X
• ISSN: 0959-440X
• Language: English
• Keywords: Oxygenases; Enzyme Inhibitors; Humans; Protein Structure, Secondary; Animals; Protein Binding; Protein Engineering