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A leukocyte-mimetic magnetic resonance imaging contrast agent homes rapidly to activated endothelium and tracks with atherosclerotic lesion macrophage content

Abstract:

Objective-Endothelial cell activation is an important mediator of monocyte recruitment to sites of vascular inflammation. We hypothesized that high-affinity dual-ligand microparticles of iron oxide (MPIO), targeted to P-selectin and vascular cell adhesion molecule-1 (PV-MPIO), would identify activated endothelial cells during atherosclerosis progression. Methods and Results-In vivo magnetic resonance imaging in apolipoprotein E-deficient mice showed rapid binding of PV-MPIO to the aortic root...

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Publisher copy:
10.1161/ATVBAHA.111.241844

Authors


McAteer, MA More by this author
Ruparelia, N More by this author
Jefferson, A More by this author
Nugent, HB More by this author
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Journal:
Arteriosclerosis, Thrombosis, and Vascular Biology
Volume:
32
Issue:
6
Pages:
1427-1435
Publication date:
2012-06-05
DOI:
EISSN:
1524-4636
ISSN:
1079-5642
URN:
uuid:2cdfd38c-467c-454b-bec6-8b1a675fcc70
Source identifiers:
335171
Local pid:
pubs:335171

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