- Abstract:
-
Insulin secretion by pancreatic islet β cells is critical for glucose homeostasis, and a blunted β cell secretory response is an early deficit in type 2 diabetes. Here, we uncover a regulatory mechanism by which glucose recruits vascular-derived neurotrophins to control insulin secretion. Nerve growth factor (NGF), a classical trophic factor for nerve cells, is expressed in pancreatic vasculature while its TrkA receptor is localized to islet β cells. High glucose rapidly enhances NGF secretio...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
- Files:
-
-
(pdf, 366.8KB)
-
- Publisher copy:
- 10.1016/j.devcel.2016.10.003
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
- Publisher:
- Elsevier (Cell Press) Publisher's website
- Journal:
- Developmental Cell Journal website
- Volume:
- 39
- Issue:
- 3
- Pages:
- 329-345
- Publication date:
- 2016-11-07
- Acceptance date:
- 2016-10-06
- DOI:
- EISSN:
-
1878-1551
- ISSN:
-
1534-5807
- Pubs id:
-
pubs:659925
- URN:
-
uri:2cdc8a68-267b-4141-a98a-f6e417c3a0fe
- UUID:
-
uuid:2cdc8a68-267b-4141-a98a-f6e417c3a0fe
- Local pid:
- pubs:659925
- Paper number:
- 3
- Language:
- English
- Keywords:
- Copyright holder:
- Elsevier
- Copyright date:
- 2016
- Notes:
- © 2016 Elsevier Inc. All rights reserved. This is the accepted manuscript version of the article, available under an Elsevier user license. The final version is available online at: [10.1016/j.devcel.2016.10.003]
Journal article
Neurotrophin Signaling Is Required for Glucose-Induced Insulin Secretion.
Actions
Access Document
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
Bibliographic Details
Item Description
Terms of use
If you are the owner of this record, you can report an update to it here: Report update to this record