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Neurotrophin Signaling Is Required for Glucose-Induced Insulin Secretion.

Abstract:

Insulin secretion by pancreatic islet β cells is critical for glucose homeostasis, and a blunted β cell secretory response is an early deficit in type 2 diabetes. Here, we uncover a regulatory mechanism by which glucose recruits vascular-derived neurotrophins to control insulin secretion. Nerve growth factor (NGF), a classical trophic factor for nerve cells, is expressed in pancreatic vasculature while its TrkA receptor is localized to islet β cells. High glucose rapidly enhances NGF secretio...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/j.devcel.2016.10.003

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
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Grant:
P30 DK079637; R01 DK108267
Publisher:
Elsevier (Cell Press) Publisher's website
Journal:
Developmental Cell Journal website
Volume:
39
Issue:
3
Pages:
329-345
Publication date:
2016-11-07
Acceptance date:
2016-10-06
DOI:
EISSN:
1878-1551
ISSN:
1534-5807
Pubs id:
pubs:659925
URN:
uri:2cdc8a68-267b-4141-a98a-f6e417c3a0fe
UUID:
uuid:2cdc8a68-267b-4141-a98a-f6e417c3a0fe
Local pid:
pubs:659925
Paper number:
3

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