Journal article
Neurotrophin Signaling Is Required for Glucose-Induced Insulin Secretion.
- Abstract:
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Insulin secretion by pancreatic islet β cells is critical for glucose homeostasis, and a blunted β cell secretory response is an early deficit in type 2 diabetes. Here, we uncover a regulatory mechanism by which glucose recruits vascular-derived neurotrophins to control insulin secretion. Nerve growth factor (NGF), a classical trophic factor for nerve cells, is expressed in pancreatic vasculature while its TrkA receptor is localized to islet β cells. High glucose rapidly enhances NGF secretio...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 366.8KB)
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- Publisher copy:
- 10.1016/j.devcel.2016.10.003
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Authors
Funding
Bibliographic Details
- Publisher:
- Cell Press Publisher's website
- Journal:
- Developmental Cell Journal website
- Volume:
- 39
- Issue:
- 3
- Pages:
- 329-345
- Publication date:
- 2016-11-07
- Acceptance date:
- 2016-10-06
- DOI:
- EISSN:
-
1878-1551
- ISSN:
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1534-5807
- Source identifiers:
-
659925
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:659925
- UUID:
-
uuid:2cdc8a68-267b-4141-a98a-f6e417c3a0fe
- Local pid:
- pubs:659925
- Deposit date:
- 2017-02-28
Terms of use
- Copyright holder:
- Elsevier
- Copyright date:
- 2016
- Notes:
- © 2016 Elsevier Inc. All rights reserved. This is the accepted manuscript version of the article, available under an Elsevier user license. The final version is available online at: [10.1016/j.devcel.2016.10.003]
- Licence:
- Other
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