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Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis. The CB0006 Sepsis Syndrome Study Group.

Abstract:

OBJECTIVES: To determine the safety, pharmacokinetics, and activity of an anti-tumor necrosis factor (TNF)-alpha monoclonal antibody in severe sepsis. DESIGN: Open-label, prospective, phase II multicenter trial with escalating doses of a murine monoclonal antibody (CB0006). SETTING: Twelve academic medical center intensive care units in the United States and Europe. PATIENTS: Eighty patients with severe sepsis or septic shock who received standard supportive care and antimicrobial therapy in ...

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Publication status:
Published

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Journal:
Critical care medicine
Volume:
21
Issue:
3
Pages:
318-327
Publication date:
1993-03-05
DOI:
EISSN:
1530-0293
ISSN:
0090-3493
URN:
uuid:2cc4a837-9281-4a52-a3d1-01c8a5759443
Source identifiers:
177189
Local pid:
pubs:177189

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