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Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells.

Abstract:

Regulatory T cells (Tregs) can potentially migrate to the B cell areas of secondary lymphoid tissues and suppress T cell-dependent B cell Ig response. T cell-dependent Ig response requires B cell stimulation by Th cells. It has been unknown whether Tregs can directly suppress B cells or whether they must suppress Th cells to suppress B cell response. We report here that Foxp3+ Tregs are found in T-B area borders and within germinal centers of human lymphoid tissues and can directly suppress B...

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Publisher copy:
10.4049/jimmunol.175.7.4180

Authors


Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
175
Issue:
7
Pages:
4180-4183
Publication date:
2005-10-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:2cc2d207-2938-4ddb-a900-cc7a0f5c73c0
Source identifiers:
246405
Local pid:
pubs:246405

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